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Mean (%) change from baseline in the multiple ascending dose regimen of fesomersen. Data are from Liu, Q. et al. [36].
| FXI Antigen Reduction | FXI Activity Reduction | aPTT Prolongation | |
|---|---|---|---|
| Placebo (pooled, n = 9) | 3 | 3 | 1 |
| Fesomersen 50 mg (n = 9) | 31 (p = 0.0013) | 15 (p = 0.1) | 8 (p = 0.14) |
| Fesomersen 100 mg (n = 9) | 54 (p < 0.0001) | 45 (p < 0.0001) | 18 (p = 0.0078) |
| Fesomersen 200 mg (n = 9) | 78 (p < 0.0001) | 71 (p < 0.0001) | 67 (p < 0.0001) |
