Table 4.
Uni/multi-variate logistic regression analysis of factors associated with high-grade fibrosis.
| Univariable Logistic Regression | |||||
|---|---|---|---|---|---|
| Variable | n | Coefficient | Se (Coefficient) | Odds Ratio (95% CI) | p-Value |
| CD68_HLA-DR_OX40L_Phospho-c-RAF_STING_Tim-3 (low vs. high) | 64 | 4.178 | 0.859 | 65.25 (12.11–351.49) | 1.16 × 10−6 |
| Age (≤55 years vs. >55 years) | 64 | −0.945 | 0.543 | 0.39 (0.13–1.13) | 0.082 |
| Sex (male vs. female) | 64 | −0.714 | 0.568 | 0.49 (0.16–1.49) | 0.208 |
| Etiology | |||||
| CHB (absent vs. present) | 64 | 0.397 | 0.559 | 1.49 (0.50–4.45) | 0.477 |
| CHC (absent vs. present) | 64 | −16.695 | 1696.734 | 0.00 (0.00–Inf) | 0.992 |
| Alcohol (absent vs. present) | 64 | −0.507 | 0.949 | 0.60 (0.09–3.87) | 0.593 |
| Others (absent vs. present) | 64 | 0.145 | 0.665 | 1.16 (0.31–4.25) | 0.828 |
| BMI (≤25 kg/m2 vs. >25 kg/m2) | 64 | 1.122 | 0.575 | 3.07 (0.99–9.48) | 0.051 |
| Diabetes (absent vs. present) | 64 | 0.734 | 0.586 | 2.08 (0.66–6.57) | 0.210 |
| ALT (<31(F), <41(M) IU/L vs. ≥31(F), ≥41(M) IU/L) | 64 | 0.029 | 0.513 | 1.03 (0.38–2.81) | 0.955 |
| AST (<31(F), <37(M) IU/L vs. ≥31(F), ≥37(M) IU/L) | 64 | −0.029 | 0.513 | 0.97 (0.36–2.65) | 0.955 |
| GGT (<50 IU/L vs. ≥ 50 IU/L) | 58 | 0.462 | 0.603 | 1.59 (0.49–5.17) | 0.443 |
| Albumin (<4.0 g/dL vs. ≥ 4.0 g/dL) | 64 | 0.366 | 0.511 | 1.44 (0.53–3.92) | 0.475 |
| Platelets (<150 × 109/L vs. ≥150 × 109/L) | 64 | −0.463 | 0.532 | 0.63 (0.22–1.79) | 0.384 |
| Cholesterol (<200 mg/dL vs. ≥200 mg/dL) | 62 | 0.256 | 0.650 | 1.29 (0.36–4.62) | 0.693 |
| Multivariable Logistic Regression | |||||
| Variable | Coefficient | Odds Ratio (95% CI) | p -Value | ||
| CD68_HLA-DR_OX40L_Phospho-c-RAF_STING_Tim-3 (Low vs. High) | 4.646 | 104.13 (14.29–758.66) | 4.54 × 10−6 | ||
| Age (≤55 years vs. >55 years) | −0.558 | 0.57 (0.10–3.29) | 0.532 | ||
| BMI (≤25 kg/m2 vs. >25 kg/m2) | 2.097 | 8.15 (1.28–51.93) | 0.026 | ||
Abbreviation: ALT, alanine aminotransferase; AST, aspartate aminotransferase; body mass index, BMI; chronic hepatitis B, CHB; chronic hepatitis C, CHC; CI, confidence interval; gamma glutamyl transferase, GGT.