%Vol	Percentage relative volume
2DE	Two-dimensional electrophoresis
2D	Two-dimensional
ACN	Acetonitrile
ACO2	Mitochondrial aconitase
AD	Alzheimer disease
ALS	Amyotrophic lateral sclerosis
AP-1	Activator protein 1
APP	Amyloid-beta precursor protein
ATPB	ATP synthase subunit beta, mitochondrial
BMP	Bone morphogenetic protein
CHAPS	3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate
CHCA	α-cyano-4-hydroxycinnamic acid
CNP	2′,3′-cyclic-nucleotide 3′-phosphodiesterase
CNS	Central nervous system
DTE	1,4-Dithioerythritol
DPYSL2	Dihydropyrimidinase-Related Protein 2
DUB	Deubiquitinase
ER	Endoplasmic reticulum
ERAD	Endoplasmic reticulum-associated degradation
FC	Fold change
GALC	Galactosylceramidase
GalCer	Galactosylceramide
GFAP	Glial fibrillary acidic protein
GWAS	Genome-wide association studies
HIF-1A	Hypoxia-inducible factor 1-alpha
Het	Heterozygous mice (galc +/−)
HRM-PCR	High resolution melting polymerase chain reaction
IBMPFD	Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia 1
IEF	Isoelectrofocusing
IF	Intermediate filament
KD	Krabbe disease
LacCer	Lactosylceramide
LB	Lewy body
LSD	Lysosomal storage disease
MALDI	Matrix assisted laser desorption/ionization
MAP	Microtubule-associated-protein
MBP	Myelin basic protein
NDRG1	N-myc downstream regulated 1
NS	Nervous system
OS	Oxidative stress
p47	NSFL1 cofactor p47
PBS	Phosphate buffer saline
PC1	First principal component
PC2	Second principal component
PC3	Third principal component
PCA	Principal component analysis
PCs	Principal components
PD	Parkinson disease
PDC	Pyruvate dehydrogenase complex
PHS	Public health service
PKC	Protein kinase C
PFE	Plasma fibrinogen extravasation
PMF	Peptide mass fingerprinting
PN	Proteostasis network
PNS	Peripheral nervous system
PP2A	Protein phosphatase 2A
Psy	Psychosine
PwMS	People with multiple sclerosis
RACK1	Receptor of activated protein c kinase 1
SDS	Sodium dodecyl sulfate
SPN	Shortest-path-network
STAT1	Activator of transcription-1
STAT3	Activator of transcription-3
TCA	Tricarboxylic acid
TCTP	Translationally-controlled tumor protein
TOF	Time of flight
TW	Homozygous twitcher mice (galc −/−)
UCHL5	Ubiquitin carboxyl-terminal hydrolase 5
UPS	Ubiquitination proteasome system
VCP	Transitional endoplasmic reticulum ATPase; alternative name: valosin-containing protein
VIME	Vimentin
WB	Western blot
WT	Homozygous wild-type mice (galc +/+)