Table 1.
Summary of animal research focusing on neurogenesis, neuroplasticity, and cognition.
No. | Strain | Sex | Age | Physical Activity | Stress Model | Main Outcome | Reference |
---|---|---|---|---|---|---|---|
1 | C57BL/6J | male | 5 weeks | swimming | unpredictable mild stress | modulation of AKT/GSK-3β/CRMP2 pathway; maintaining microtubule dynamics | [58] |
2 | C57BL/6J | male | N/A | treadmill | restraint stress | attenuated hippocampal cell death; CREB activation; decreased ROS levels | [60] |
3 | Long–Evans | female | 7 weeks | voluntary wheel running | traumatic stress | ameliorated stress-induced maladaptive behaviours | [57] |
4 | Sprague–Dawley | male | 2.5 months | treadmill | predator scent stress | improved morphological features of neurons | [59] |
AKT—AKT kinase; CREB—cAMP response element-binding protein; GSK-3β—glycogen synthase kinase-3β; ROS—reactive oxygen species.