Table 3.

Sensitivity analysis according to time from injury to blood sample collection.

	Time from Injury to Blood Sample Collection
	0–18 h (N= 475)	0–12 h (N = 456)	0–6 h (N = 414)
	Adjusted OR (95% CI)	Adjusted OR (95% CI)	Adjusted OR (95% CI)
6-month mortality
Low, 0.0~79.9 mcg/dL	1.76 (1.47–2.10)	1.80 (1.49–2.17)	1.90 (1.62–2.24)
Low–normal, 80.0~100.0 mcg/dL	1.04 (0.62–1.76)	1.01 (0.56–1.82)	1.03 (0.59–1.79)
High–normal, 100.1~120.0 mcg/dL	1.00	1.00	1.00
High, 120.1~ mcg/dL	0.69 (0.42–1.15)	0.74 (0.47–1.16)	0.83 (0.55–1.25)
6-month disability, GOS 1–3
Low, 0.0~79.9 mcg/dL	1.77 (1.48–2.12)	1.80 (1.47–2.21)	1.83 (1.43–2.35)
Low–normal, 80.0~100.0 mcg/dL	1.05 (0.83–1.33)	1.01 (0.77–1.31)	1.13 (0.88–1.44)
High–normal, 100.1~120.0 mcg/dL	1.00	1.00	1.00
High, 120.1~ mcg/dL	0.84 (0.57–1.25)	0.84 (0.59–1.21)	0.98 (0.70–1.36)
1-month mortality
Low, 0.0~79.9 mcg/dL	2.32 (1.78–3.03)	2.43 (1.80–3.28)	2.39 (1.85–3.09)
Low–normal, 80.0~100.0 mcg/dL	1.29 (0.68–2.44)	1.28 (0.63–2.60)	1.19 (0.63–2.26)
High–normal, 100.1~120.0 mcg/dL	1.00	1.00	1.00
High, 120.1~ mcg/dL	0.81 (0.44–1.48)	0.88 (0.50–1.53)	0.97 (0.60–1.57)
1-month disability, GOS 1–3
Low, 0.0~79.9 mcg/dL	1.73 (1.30–2.30)	1.90 (1.56–2.31)	1.81 (1.53–2.13)
Low–normal, 80.0~100.0 mcg/dL	1.20 (0.82–1.76)	1.20 (0.94–1.54)	1.30 (0.98–1.72)
High–normal, 100.1~120.0 mcg/dL	1.00	1.00	1.00
High, 120.1~ mcg/dL	0.88 (0.52–1.49)	0.94 (0.60–1.48)	1.06 (0.67–1.68)

Adjusted for age, sex, education, pre-injury disability, injury severity (head AIS), and comorbidities (hypertension, diabetes mellitus, and chronic liver disease). Abbreviations: OR—odds ratio; CI—confidence interval; GOS—Glasgow outcome scale.