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. 2022 Nov 1;23(21):13364. doi: 10.3390/ijms232113364

Figure 1.

Figure 1

The suppressive effect of THGP on the inflammasome via signaling step 2. (a) The secretion of IL-1β from THP-1 cells was measured by ELISA after stimulation with 10 μg/mL LPS, 5 mM ATP, or the combination of the two. THGP was added at a concentration of 0–12 mM. (b) The secretion of IL-1β from THP-1 cells was measured by ELISA after stimulation with 10 μg/mL LPS and 1 mM ATP. THGP was added at a concentration of 0–5 mM. (c) The secretion of IL-1β from RAW 264.7 cells was measured by ELISA after stimulation with 10 μg/mL LPS and 1 mM ATP. THGP was added at a concentration of 5 mM. (d) The effect of THGP on the mRNA expression of IL-1β in THP-1 cells treated with 10 μg/mL LPS and 5 mM THGP was investigated by real-time RT–PCR. (e) The secretion of IL-6 from THP-1 cells was measured by ELISA after stimulation with 10 μg/μL LPS and/or 5 mM ATP. THGP was added at a concentration of 5 mM. The mean and S.D. are shown. n = 6. ** p < 0.01.