FIG. 3.

Effect of injection of 3T3-CD40L transfectants in T. cruzi-infected mice. Three groups of mice were inoculated with T. cruzi and injected with either 3T3-CD40L transfectants, 3T3 control fibroblasts, or PBS. Parasitemia (A) and cumulative survival (B) are reported. Dotted lines represent the parasitemia when less than 50% of mice were still alive. Data were pooled from three independent experiments (n = 14 or 15 mice per group). For parasitemia, the difference between the experimental and control groups was significant (P < 0.01, Mann-Whitney U test) for the period from day 15 to day 24 p.i. ∗∗, P < 0.002 (χ² analysis).