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Effect of injection of neutralizing anti-IL-12 MAb on T. cruzi-infected and 3T3-CD40L transfectant-treated mice. Mice (n = 10) were inoculated with T. cruzi trypomastigotes and injected with 3T3-CD40L transfectants or 3T3 control fibroblasts. Neutralizing anti-IL-12 MAb or isotype-matched control was injected intraperitoneally on the day of infection (day 0) and then on days 2 and 4 p.i. Cumulative survival was reported. ∗, P < 0.05 (χ2 analysis).
