TABLE 3.

Effect of activating anti-CD40 MAb on IFN-γ-activated MPM^a

Treatment	Parasitic index		Nitrite (μM)
	Isotype control	Anti-CD40 MAb	Isotype control	Anti-CD40 MAb
None	377 ± 53	118 ± 30**	23.6 ± 1.3	43.1 ± 4.4**
NAME	459 ± 81	428 ± 93	6.4 ± 3.6	7.7 ± 3.9
Anti-IL-12 MAb	355 ± 104	115 ± 11**	23.9 ± 3.0	41.5 ± 7.1**

^aMPM were treated at the time of T. cruzi infection with 10 U of rIFN-γml in combination with isotype-matched control MAb or FGK45 anti-CD40 MAb in the presence or absence of NAME or neutralizing anti-IL-12 MAb. Parasitic index and nitrite levels were measured. Data are from three independent experiments performed in duplicate. ∗∗, P < 0.01 compared to isotype-matched control MAb (Student’s t test).