Table 2.
Components of glycocalyx and its association with tumor microenvironment.
| Cancer Type | Components | Pathway | Function | Ref. |
|---|---|---|---|---|
| Multiple myeloma | SDC1 | HGF/c-met/IL-11 | ECM remodeling | [60] |
| Breast cancer | SDC1 | TGF-β | ECM remodeling | [61] |
| Breast cancer | SDC1 | FGF2, SDF1 | Growth signal | [62] |
| Bladder cancer | SDC4 | NF-κB | ECM deposition of Tenascin-C | [63] |
| Pancreatic ductal adenocarcinoma | SDC1 | CCL5 | Mediate the T cells crosstalk with tumor cells | [64] |
| Breast cancer | SDC2 | TGF-β | Immune evasion | [65] |
| Melanoma | SDC3 | Proinflammatory response | [66] | |
| Colon cancer | SDC1 | VEGFR2 | Angiogenesis | [67] |
| Colon cancer | SDC2 | VEGF | Angiogenesis | [68] |