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. 2022 Nov 2;23(21):13389. doi: 10.3390/ijms232113389

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of huMETCAM/MUC18′s over-expression on in vivo tumorigenesis. Tumorigenicity of the METCAM clone #92 and the vector control clone #V1 of the NPC-TW01 cells was determined by subcutaneous injection of the cells from each clone at the dorsal side in male athymic nude mice. (a) The tumor proliferation by the two clones by plotting mean tumor volumes/weights versus time after injection is shown. p-values were determined between tumor volumes through the time course of the METCAM clone #92 and that of the vector control clone V1. (b) The mice bearing tumors of the METCAM clone #92 and the vector control clone V1 and the excised tumors are shown. (c) The mean final tumor weights of the two clones in the athymic nude mice were compared at the endpoint. Both the mean final tumor weights from five mice of the vector control clone V1 were statistically significantly heavier than the mean tumor weights from those of the METCAM clone #92 since the p-value was 0.007.

Effects of huMETCAM/MUC18′s over-expression on in vivo tumorigenesis. Tumorigenicity of the METCAM clone #92 and the vector control clone #V1 of the NPC-TW01 cells was determined by subcutaneous injection of the cells from each clone at the dorsal side in male athymic nude mice. (a) The tumor proliferation by the two clones by plotting mean tumor volumes/weights versus time after injection is shown. p-values were determined between tumor volumes through the time course of the METCAM clone #92 and that of the vector control clone V1. (b) The mice bearing tumors of the METCAM clone #92 and the vector control clone V1 and the excised tumors are shown. (c) The mean final tumor weights of the two clones in the athymic nude mice were compared at the endpoint. Both the mean final tumor weights from five mice of the vector control clone V1 were statistically significantly heavier than the mean tumor weights from those of the METCAM clone #92 since the p-value was 0.007.