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. 2022 Oct 28;14(21):4549. doi: 10.3390/nu14214549

Figure 3.

Figure 3

L-cit restrains ferritinophagy induced by iron overload in mouse thymus. Mice were intraperitoneally injected with iron dextran 50 mg/kg, and L-cit was given by gavage administration with a dosage of 0.5, 1.0, and 2.0 g/kg/day. Immunoblot analyses were explored. (A,B) Immunoblot analyses of FTH. (A,C) Immunoblot analyses of TfR1. (A,D) Immunoblot analyses of NCOA4. (A,E) Immunoblot analyses of LC3. (A,F) Immunoblot analyses of GPX4. GAPDH was used as the loading control. Values represent mean ± SEM. of three independent experiments. Significant differences are represented by * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns (not significant).