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. 2022 Oct 24;23(21):12784. doi: 10.3390/ijms232112784

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Gene set variation analysis (GSVA) of the selected PRGs with clinical value between different pathologic stages in LIHC and other digestive system cancers. (A) Original GSVA score between tumor and paracancerous tissues. (B) GSVA-altered pathways in different cancer types from digestive system. (C) GSVA trend analysis of 61 polarity-related genes across digestive system cancers. (D) Detailed trend analysis in LIHC cohort showed difference between pathological stages. *, p < 0.05; #, FDR < 0.05.