Table 1.
(A) Electrical parameters (electrode size A, relative permittivity εr, and electric conductivity σ) required to calculate the capacitances C in vitro and in vivo and to simulate E-field distributions. (B) List of thermal parameters required to calculate the temperature distributions for the in vivo applicator, which is applied for nude mice.
| (A) | |||
| Electrical Parameters | In Vitro Applicator | In Vivo Applicator | |
| electrodes upper electrode counter electrode |
grid-shaped electrodes (steel) 4 × 1.6 × 0.75 cm2 electrode area reduced by 0.75 |
stainless steel ø 1 = 1 cm, h = 6 cm ø 2 = (ø 12 + d2)1/2 |
|
| distance d (cm) between electrodes | 1.3 | 1.2 (mouse) | |
| RPMI-Medium between electrodes | εr = 72.5, σ = 1.2 S/m | εr = 100 (2/3 medium) εr = 79 (phantom) |
|
| additional interfaces | coverslips, polyolefin 2 × 0.2 mm, εr = 2 |
silver plated cotton 0.2 mm, εr = 2 |
|
| (B) | |||
| Thermal Parameters | In Vivo Applicator | ||
| Thermal conductivity λ (W/m/°C) | Electrode (steel): 20 Cover (silver plated cotton): 90 Tissue (mixture muscle/fat): 0.5 |
||
| Heat capacitance c (Ws/kg/°C) | Electrode (steel): 420 Tissue: 3600 |
||
| Heat transfer HTC (W/m2/°C) | Mouse body: 6 | ||
| Perfusion (mL/100 g/min) | Tissue: 100 | ||
| Heat generation (W/kg) | Tissue: 10 | ||