Figure 16.

(a) Binding pose architecture of OEU and OC on the crystal structure of SARS-CoV-2 Omicron mt variants BA.1 and BA.2 of S protein’s RBD in complex with ACE2 host receptor protein (PDB IDs: 7WPB and 7XO9, respectively). ACE2 protein is illustrated in deep-salmon cartoon, while RBD protein is depicted in orange cartoon. OEU and OC are rendered in sphere mode colored by atom type in hot pink and yellow-orange, respectively. Selected binding residues of OEU and OC on Omicron BA.1 variant are highlighted in the cartoon. Hydrogen atoms are omitted from all molecules, and sugar molecules glycosylating the protein are hidden for clarity. Heteroatom color code: O—red. The final structure was ray-traced and illustrated with the aid of PyMol Molecular Graphics Systems. (b) Schematic 2D interaction diagrams showing the binding contacts of OEU and OC on SARS-CoV-2 Omicron mt variant BA.1 of S protein’s RBD in complex with ACE2 host receptor protein (PDB IDs: 7WPB). The final structure was illustrated with the aid of BIOVIA Discovery Studio 2016.