Figure 17.

(a) Binding pose architecture of OEU and OC on the crystal structure of SARS-CoV-2 Omicron mt variants BA.2 of S protein’s RBD in complex with ACE2 host receptor protein (PDB ID: 7ZF7). ACE2 protein is illustrated in dark-salmon cartoon, while RBD protein is depicted in violet-purple cartoon. OEU and OC are rendered in sphere mode colored by atom type in hot-pink and yellow-orange C atoms, respectively. Hydrogen atoms are omitted from all molecules, and sugar molecules glycosylating the protein are hidden for clarity. Heteroatom color code: O—red. The final structure was ray-traced and illustrated with the aid of PyMol Molecular Graphics Systems. (b) Schematic 2D interaction diagrams showing the binding contacts of OEU and OC on SARS-CoV-2 Omicron mt variants BA.2 of S protein’s RBD in complex with ACE2 host receptor protein (PDB ID: 7ZF7). The final structure was illustrated with the aid of BIOVIA Discovery Studio 2016.