Table 2.

SiRNAs linked with anti-estrogen therapy resistance of ER+ BC.

Cancer Hallmarks	In Vitro Study	In Vivo Study	Effect(s)	Reference
MED1	+	+	Decreases cell viability, induces cell-cycle arrest, inhibits tumor growth	[266]
TRIM56	+	+	Suppresses cell proliferation and tumor growth	[267]
Wee1, CDK4, CDK7	+	+	Decreases tumor growth	[268]
MST2	+	+	Induces apoptosis and decreases tumor growth	[269]
ERα	+	+	Decreases proliferation and vascularization of solid tumors	[270]
CDK2	+	+	Inhibits cell proliferation and tumor growth	[271]
Bcl2	+	+	Inhibits cell growth and tumor growth	[272]
LEM4	+	+	Decreases cell proliferation and tumor growth	[273]
PDK1	+	-	Decreases cell proliferation	[274]
ATG5, ATG7	+	-	Inhibits autophagy	[275]
ZNF213	+	-	Inhibits cell proliferation	[276]
RBCK1	+	-	Reduces cell proliferation and G2-M arrest	[277]
S6 kinase 1	+	-	Induces cell death via glucose deprivation	[278]
USP15	+	+	Suppresses cell viability, triggers cell-cycle arrest, decreases tumor growth	[279]
AMPKα1/2	+	-	Decreases cell survival	[280]
CDK7	+	-	Decreases cell viability and increases apoptosis	[281]

+, yes; -, no.