Skip to main content
. 2022 Oct 29;11(21):6421. doi: 10.3390/jcm11216421

Figure 4.

Figure 4

ITGB2 inhibits the proliferation, migration, and invasion of NSCLC cells in vitro. (A) ITGB2 expression at the mRNA level and protein level in H1792 cells. (B) Cell viability was detected by CCK-8 assay (** p < 0.01, *** p < 0.001), and the optical density (OD) absorbance values at 450 nm were measured using a microplate reader, embodying the proliferation capacity of the cells. (C) Cell proliferation ability was detected by the EdU assay, scale bars: 50 μm (** p < 0.01). (D) The migration and invasion of H1792 cells were evaluated by a Transwell assay, scale bars: 100 μm, (* p < 0.05, ** p < 0.01). (E) The Epithelial–mesenchymal transition markers were detected by Western blot assay in H1792 cells. (F) Schematic diagram of the potential mechanisms of ITGB2-mediated inhibition of tumorigenesis in NSCLC. All representative images from at least three independent experiments. * P < 0.05, ** P < 0.01, *** P < 0.001.