Table 1.
IC50 and CLogp values of compounds 1–22, ~1000, inhibition was close to 50% at the highest tested concentration; >1000, compound was far from 50% inhibition at the highest concentration tested but activity was significant; <250, IC50 was lower than the lowest tested concentration.
| Compound | CLogp | IC50 (μM) | R2 | Compound | CLogp | IC50 (μM) | R2 |
|---|---|---|---|---|---|---|---|
| 1 | 1.903 | 518 | 0.9961 | 12 | 0.676 | >1000 | - |
| 2 | 1.186 | 572 | 0.9978 | 13 | 2.046 | <250 | - |
| 3 | 0.746 | >1000 | - | 14 | 2.616 | <250 | - |
| 4 | 1.236 | >1000 | - | 15 | 2.766 | <250 | - |
| 5 | 1.822 | 334 | 0.9950 | 16 | 1.646 | >1000 | - |
| 6 | 2.616 | <250 | - | 17 | 0.639 | >1000 | - |
| 7 | 1.236 | >1000 | - | 18 | 1.085 | >1000 | - |
| 8 | 1.822 | 879 | 0.9990 | 19 | 2.445 | 488 | 0.9987 |
| 9 | 2.402 | 415 | 1.000 | 20 | 2.228 | 484 | 0.9979 |
| 10 | 2.786 | <250 | - | 21 | 2.808 | 511 | 0.9981 |
| 11 | 1.336 | ~1000 | - | 22 | 1.712 | ~1000 | - |