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. 2022 Oct 27;23(21):13055. doi: 10.3390/ijms232113055

Figure 4.

Figure 4

The mRNA expression of key inflammatory factors and iNOS+ cells after depletion of Arg1+ microglia/macrophages or not. (A) Relative mRNA levels of anti-inflammatory factors Arg1, IL-10, and TGF-β. The mRNA expression of Arg1 and IL-10 decreased when Arg1+ microglia/macrophages were depleted, while no significant differences were found in TGF-β. However, ischemia itself induced a great increase of inflammatory factors (n = 3). (B) Relative mRNA levels of pro-inflammatory factors iNOS, IL-1β, and TNF. As Arg1+ microglia/macrophages were depleted, the mRNA expression of pro-inflammatory factors significantly elevated four days after stroke. (C) Representative confocal images showing iNOS+ cells in brain slices administrated with MLs or MCLs after stroke. (D) The density of iNOS+ cells after MLs or MCLs treatment. MCLs caused a rise of iNOS+ cells (n = 3, * p < 0.05, ** p < 0.01).