Table 1.

Inhibition parameters of the novel synthesized bromophenols (13–21) against AChE, hCA I, and hCA II enzymes.

Compounds	IC50 (nM)						Ki (nM)
	hCA I	r2	hCA II	r2	AChE	r2	hCA I	hCA II	AChE
13	38.50	0.9848	21.00	0.9778	14.74	0.9862	25.67 ± 4.58	1.63 ± 0.11	11.04 ± 0.61
14	19.80	0.9833	14.74	0.9821	11.95	0.9743	2.53 ± 0.25	4.28 ± 0.86	11.62 ± 2.75
15	20.38	0.9837	15.07	0.9870	13.08	0.9734	9.35 ± 1.88	2.62 ± 0.13	24.86 ± 5.30
16	21.00	0.9748	15.75	0.9817	13.86	0.9882	12.80 ± 0.52	7.77 ± 0.57	16.27 ± 2.98
17	27.72	0.9845	23.10	0.9824	21.00	0.9767	18.76 ± 4.97	10.33 ± 1.88	21.04 ± 4.72
18	15.40	0.9714	11.36	0.9972	8.35	0.9825	12.49 ± 0.66	9.15 ± 1.36	7.92 ± 1.38
19	31.50	0.9868	27.72	0.9800	20.38	0.9871	20.35 ± 2.92	15.05 ± 1.07	17.43 ± 3.15
20	19.25	0.9812	14.14	0.9841	11.75	0.9921	13.37 ± 2.29	6.21 ± 1.01	8.32 ± 0.69
21	12.38	0.9783	7.45	0.9836	9.90	0.9869	11.00 ± 3.83	4.97 ± 0.59	6.54 ± 1.03
Acetazolamide	48.15	0.9812	30.12	0.9856	-	-	40.44 ± 4.67	28.13 ± 3.56	-
Tacrine	-	-	-	-	38.45	0.9756	-	-	32.44 ± 2.13
Donepezil	-	-	-	-	23.05	0.9989			17.93 ± 2.83