Skip to main content
. 2022 Nov 1;14(21):5388. doi: 10.3390/cancers14215388

Figure 3.

Figure 3

Chromosomal instability signature and cyclin D1 expression in breast cancer subtypes. (A) Heatmap of breast cancer microarray datasets assigned to the breast cancer coding genome expression subtypes. The predicted ESR1, epidermal growth factor receptor (ERBB2), and progesterone receptor (PGR) statuses are shown together with a chromosomal instability gene signature (CIN) signature score and CCND1 expression level across the 5 subtypes. The CIN signature score, and cyclin D1 expression level are outlined for the luminal B subtype. (B) CCND1 transcript level plotted vs. CIN signature expression level show a correlation between high CIN score and high cyclin D1 expression in luminal B subtype specific (red circle).