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. 2022 Nov 5;27(21):7599. doi: 10.3390/molecules27217599

Scheme 1.

Scheme 1

Synthesis of neocryptolepine 5. Reagents and conditions: (a) N-chlorosuccinimide, 1,4-dimethylPiperazine, CH2Cl2, 0 °C, 2 h. b. Trichloroacetic acid, room temperature, 2 h. (b) Diphenyl ether, reflux, 3 h. (c) POCl3, toluene, reflux, 12 h.