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. 2022 Nov 5;27(21):7599. doi: 10.3390/molecules27217599

Scheme 9.

Scheme 9

Plausible mechsm of hybrids 11ad formation via Knoevenagel condensation reaction with aldehydes 10a,b. where R = alkylene amino neocryptolepine, Ar = Ph or 4-hydroxyphenyl.