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. 2022 Oct 25;23(21):12870. doi: 10.3390/ijms232112870

Figure 7.

Figure 7

The influence of stretch-activated channel inhibitors ruthenium red (A) and gadolinium (B), and a selective piezo channel inhibitor GsMTx4 (C) on the Rb uptake response to Yoda1 in cultured lens epithelium. Cells were exposed to Yoda1 (1 µM) in Rb-containing Krebs solution ± ruthenium red (50 μM) for 10 min. Some cells were exposed to Yoda1 (1 µM) in Rb-containing, bicarbonate-free, HEPES-buffered Krebs solution ± gadolinium (50 µM) for 10 min. Another group of cells was exposed to Yoda1 (1 µM) in Rb-containing Krebs solution ± GsMTx4 (5 µM) for 10 min. The values are the mean ± SEM of results from 6 independent experiments. *** and ** indicate significant differences (p < 0.001 and p < 0.01, respectively) from the control (no Yoda1); ### and ## indicate significant differences (p < 0.001 and p < 0.01, respectively) from Yoda1 treatment as determined by one-way ANOVA followed by Šídák’s multiple comparison test.