Figure 8.

Angiotensin II contractile effect (expressed as percentage of change) in the ileum, proximal colon (PC), middle colon (MC) and distal colon (DC) of control (CTRL, n = 5–8) and streptozotocin-induced diabetic rats (STZ, n = 4–6) in the presence of the following antagonists: (a) candesartan (AT₁R antagonist, 10 nM) and (b) PD123,319 (AT₂R antagonist, 100 nM). Values are mean ± SEM. For statistical analysis we used a paired t test between the effect in the absence and presence of the antagonist.* p < 0.05 vs. the correspondent response to Angiotensin II in the absence of the antagonist.