Table 2.
Emax (mN/g) and EC50 (μM) values of smooth muscle contraction induced by Angiotensin II application in the ileum, proximal colon, middle colon, and distal colon of control (CTRL, n = 5–8) and streptozotocin-induced diabetic rats (STZ, n = 5).
| Ileum | Proximal Colon | Middle Colon | Distal Colon | |
|---|---|---|---|---|
| Control | ||||
| Emax (mN/g) | 305.3 [138.6–620.5] | 181.5 [136.0–297.0] | 276.6 [246.4–451.1] | 344.4 [222.4–433.5] |
| EC50 (μM) | 8.29 [1.24–24.68] | 1.10 [0.36–2.12] | 3.80 [1.95–4.76] | 40.50 [17.08–309.3] |
| STZ | ||||
| Emax (mN/g) | 71.20 [12.3–100.6] * | 50.46 [15.32–78.15] * | 100.6 [22.86–163.5] * | 263.5 [165.0–415.9] |
| EC50 (μM) | 7.985 [0.31–8.89] | 0.59 [0.35–14.93] | 2.60 [0.89–7.81] | 4.17 [0.84–8.38] * |
For comparison between the two experimental groups (CTRL and STZ) we used a Mann–Whitney test. Values are median (95% confidence limits). * p < 0.05 vs. correspondent control.