Table 4.
Progression-free and overall survival in the univariate analysis (Univariate cox analysis).
| Univariate Analysis | ||||
|---|---|---|---|---|
| PFS | OS | |||
| Prognostic Factor | p-Value | HR (95% CI) | p-Value | HR (95% CI) |
| GPS | <0.0001 | 4.479 (2.302–8.716) | <0.0001 | 6.153 (3.181–11.90) |
| CRP | 0.005 | 1.009 (1.003–1.016) | 0.016 | 1.008 (1.001–1.014) |
| Albumin | 0.08 | 0.950 (0.898–1.006) | 0.013 | 0.931 (0.881–0.985) |
| NLR | 0.493 | 1.016 (0.972–1.061) | 0.096 | 1.032 (0.994–1.071) |
| PLR | 0.741 | 0.999 (0.007–1.002) | 0.268 | 1.001 (0.991–1.003) |
| PNI | 0.065 | 0.963 (0.924–1.002) | 0.005 | 0.942 (0.904–0.982) |
| PI | 0.02 | 1.675 (1.093–2.566) | 0.02 | 1.663 (1.083–2.552) |
| Age > 60 years | 0.237 | 1.455 (0.782–2.707) | 0.078 | 1.793 (0.938–3.430) |
| ECOG PS ≥ 2 | 0.08 | 1.860 (0.911–3.800) | <0.0001 | 3.668 (1.935–6.950) |
| CCI > 3 | 0.004 | 4.608 (1.638–12.97) | 0.006 | 7.418 (1.786–30.81) |
| UICC IV | <0.0001 | 1.698 (0.903–3.194) | <0.0001 | 1.292 (0.689–2.424) |
| NEC (G3) | 0.0004 | 3.168 (1.161–8.646) | <0.0001 | 3.817 (1.548–9.412) |
CCI, Charlson Comorbidity Index; CRP, C-reactive protein; ECOG PS, Eastern Cooperative Oncology Group performance status; GPS, Glasgow Prognostic Score; HR, hazard ratio; NLR, neutrophil–ratio; OS, overall survival; PFS, progression-free survival; PI, prognostic index; PLR, platelet–lymphocyte ratio; PNI, prognostic nutritional index; UICC, Union International Contre le Cancer. Bold values indicate statistical significance (p < 0·05) in the univariate cox analysis.