Table 5.
Overall survival and progression-free survival in the univariate analysis and consecutive multivariate Cox proportional hazard regression.
| Univariate Analysis OS | Multivariate Analysis OS | ||
|---|---|---|---|
| Prognostic Factor | p-Value | p-Value | HR (95% CI) |
| GPS | <0.0001 | <0.0001 | 3.459 (1.263–6.322) |
| PI * | 0.02 | 0.690 | 2.344 (1.513–8.436) |
| PNI ** | 0.005 | 0.409 | 0.851(0.535–4.331) |
| ECOG | <0.0001 | 0.042 | 1.667 (0.828–4.189) |
| CCI > 3 | 0.006 | 0.530 | 0.715 (0.299–6.299) |
| UICC IV | <0.0001 | 0.001 | 1.155 (0.870–1.399) |
| NEC (G3) | <0.0001 | 0.004 | 1.271 (0.930–1.661) |
| Univariate Analysis PFS | Multivariate Analysis PFS | ||
| p-Value | p-Value | HR (95% CI) | |
| GPS | <0.0001 | 0.002 | 2.119 (0.944–4.265) |
| PI * | 0.02 | 0.518 | 2.775 (1.984–4.372) |
| PNI ** | 0.065 | 0.644 | 1.384 (1.015–1.855) |
| ECOG | 0.08 | 0.453 | 2.248 (1.433–3.556) |
| CCI > 3 | 0.004 | 0.092 | 4.210 (1.936–6.501) |
| UICC IV | <0.0001 | 0.067 | 1.582 (1.214–2.737) |
| NEC (G3) | 0.0004 | 0.081 | 1.322 (0.862–2.453) |
CCI, Charlson Comorbidity Index; GPS, Glasgow Prognostic Score; OS, overall survival; PFS, progression-free survival; PI, prognostic index; PNI, prognostic nutritional Index; UICC, Union InterNational Contre le Cancer. * CRP > 10 mg/dL, white blood cell count > 11,000/μL, ** >50.