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. 2022 Nov 3;23(21):13465. doi: 10.3390/ijms232113465

Figure 1.

Figure 1

Timeline of DOXO treatment and blood collection in Wistar rats (A). Representative picture of Western blot of Bax, cleaved caspase-3, pro caspase-3, and GAPDH from heart tissues of saline-treated (SAL) and DOXO-treated (DOXO) rats (B). Fold change of band intensities of Bax relative to GAPDH (C), cleaved caspase-3 relative to GAPDH (D), pro caspase-3 relative to GAPDH (E) in SAL (n = 5) and DOXO (n = 5) groups. Concentration of NT-proBNP in serum of SAL (n = 5) and DOXO (n = 5) groups (F); * p < 0.05 vs. SAL. The effect of Doxorubicin on left ventricular function and cardiac sympathovagal balance (G–L). (G). LVEF (%), (H). LVFS (%), (I). E/A ratio, (J). LF (normalized unit), (F). HF (normalized unit), (G). LF/HF ratio; DOXO, doxorubicin; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening, E/A, early filling to atrial filling velocities ratio; LF/HF, low-frequency component to high-frequency component ratio. Data are presented as the mean ± SEM; * p < 0.05 vs. baseline; † p < 0.05 vs. SAL at that period of time.