Table 1.
Sensitivity profile of different molecular subtypes of KIT or PDGFRA GISTs.
| Molecular GIST Sub-Type | Treatment | ||||
|---|---|---|---|---|---|
| Imatinib [14,31,43] | Sunitinib [45] | Regorafenib [53] | Ripretinib [50] | Avapritinib [51] | |
| KIT Mutations | |||||
| Exon 9 | ✓ | - | - | - | - |
| Exon 11 | ✓ | - | - | - | - |
| Exon 13 (V654) | ✕ | ✓ | ✕ | ✓ | - |
| Exon 14 (T670) | ✕ | ✓ | ✓ | ✓ | - |
| Exon 17 (D816) | ✕ | ✕ | ✓/✕ | ✓/✕ | - |
| Exon 17 (D820) | ✕ | ✕ | ✓ | ✓ | - |
| Exon 17 (N822) | ✕ | ✕ | ✓ | ✓ | - |
| Exon 17 (Y823) | ✕ | ✕ | ✓ | ✓ | - |
| Exon 18 (A829) | ✕ | ✕ | ✓ | ✓ | - |
| PDGFRA Mutations | |||||
| Exon 12 | ✓ | ✓ | ✓ | ✓ | ✓ |
| Exon 13 | ✕ | ✕ | ✕ | ✕ | ✕ |
| Exon 14 | ✕ | ✕ | ✕ | ✕ | ✕ |
| Exon 15 | ✕ | ✕ | ✕ | ✕ | ✕ |
| Exon 18 (D842V) | ✕ | ✕ | ✕ | ✕ | ✓ |
| Exon 18 (Non-D842V) | ✓ | ✓ | ✓ | ✓ | ✓ |
The checkmarks indicate drug sensitivity, and the crosses indicate drug resistance.