TABLE 3.
Immune response to vaccine strains among 170 U.S. military personnel stationed in Panama in 1996
| Parameter | Result for CVD 103-HgR/CVD 111 vaccine dose (CFU) of:
|
||||
|---|---|---|---|---|---|
| 108/107 | 108/106 | 0/107 | 108/0 | 0/0a | |
| Total no. of volunteers | 35 | 34 | 34 | 32 | 35 |
| No. (%) with preimmunization serum vibriocidal antibody titer of ≥1:40 for: | |||||
| Inaba | 14 (40.0) | 14 (41.2) | 17 (50.0) | 7 (21.9) | 14 (40.0) |
| Ogawa | 25 (71.4) | 18 (52.9) | 23 (67.6) | 18 (56.3) | 19 (54.3) |
| No. (%) with ≥fourfold increase in vibriocidal immune response for: | |||||
| Inaba | 24 (68.6) | 23 (67.6) | 13 (38.2) | 21 (65.6) | 0 (0) |
| Ogawa | 25 (71.4) | 21 (61.8) | 18 (52.9) | 17 (53.1) | 0 (0) |
| Reciprocal geometric mean titer | |||||
| Pre-Inaba | 29 | 30 | 37 | 20 | 25 |
| Post-Inaba | 525 | 453 | 196 | 550 | 25 |
| Fold increase | 18.1 | 15.1 | 5.3 | 27.5 | 1.0 |
| Pre-Ogawa | 66 | 38 | 60 | 38 | 38 |
| Post-Ogawa | 879 | 533 | 602 | 300 | 42 |
| Fold increase | 13.3 | 14.0 | 10.0 | 7.9 | 1.1 |
| No. with CT seroconversion of >0.2 (%) | 19 (54.3) | 22 (64.7) | 18 (52.9) | 12 (37.5) | 3 (8.6) |
a
0/0, E. coli placebo.