Table 1.

Effects of Semaglutide on Biochemical Parameters

Parameters	Scr (μmol/)	Ccr (mL/min)	Ua (μmol/)	TG (mmol/L)	TC (mmol/L)	LDL (mmol/L)	HDL (mmol/L)	UACR (mg/mmol)	INS0(pg/mL)	G0(mmol/L)
NFD	60.68±9.91	(2.01±0.62)%	138.19±23.97	0.64±0.10	3.15±0.39	2.19±0.47	2.86±0.61	0.18±0.06	300.05±44.02	4.36±0.59
HFD	62.72±11.46	(3.09±0.11)%*	254.63±42.34***	0.93±0.13***	8.36±1.23***	6.79±1.37***	6.94±1.18***	0.83±0.15***	411.69±143.500	7.86±1.65***
HFDS	61.37±9.66	(2.23±0.40)%	172.83±19.04###	0.72±0.16##	5.84±0.45###	4.78±0.45###	4.56±0.86###	0.38±0.13###	174.86±59.92###	6.74±1.52

Notes: *p<0.05, ***p<0.001, compared with NFD; ^##p<0.01, ^###p<0.001, compared with HFD.

Abbreviations: Scr, serum creatinine; Ua, uric acid; TG, triglyceride; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Ccr, creatinine clearance; UACR, urinary albumin/creatinine ratio; INS0, fasting plasma insulin; G0, fasting blood glucose.