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. 2022 Oct 22;23(21):12748. doi: 10.3390/ijms232112748

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Correlation analysis of J chain expression and immune profile in lung adenocarcinoma patients. (A) Spearman correlation between J chain levels and relative fraction of 22 leukocyte subtypes (LM22 signature) as computed by CIBERSORT in adenocarcinoma samples of GSE37745 (n = 106), GSE50081 (n = 129), GSE31210 (n = 246) datasets. r of Spearman correlation is color-coded and relative significance is as follows: * p < 0.05, ** p < 0.01, *** p < 0.001. (B) Representative correlation plots in samples of the GSE50081 dataset between J chain expression and B plasma cells, CD4⁺ memory-activated T cells, Treg and M2 macrophages. r of Pearson and relative p-values are shown.