Table 4.

Multivariate analysis (Cox regression) of prognostic factors for DFS and OS.

		DFS			OS
	HR	95% CI	p-Value	HR	95% CI	p-Value
Grade 1 vs. 2 vs. 3	-	-	0.560	-	-	0.977
Ki-67 ≥ 20% vs. <20%	0.8	1.8–35.5	0.006			0.260
ER ≥ 10% vs. <10%	-	-	0.072	3.2	1.3–7.7	0.008
pCR vs. no pCR	0.2	0.0–0.6	0.009	-	-	0.06
HIF-1α ≥ 5% vs. <5%	2.5	1.0–6.2	0.047	-	-	0.295
pAKT ≥ 10% vs. <10%	2.4	1.0–5.9	0.039	2.4	1.0–5.7	0.046

Abbreviations: DFS, disease-free survival; ER, estrogen receptor; HR, Hazard ratio; OS, overall survival; Italic means the p-value is significant.