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. 2022 Oct 30;23(21):13227. doi: 10.3390/ijms232113227

Figure 2.

Figure 2

Anxio-/depressive-like behavior to study venlafaxine/carbenoxolone antidepressant effect in a mouse model of depression. (A) Design of experiment. Mice were chronically treated with VEH (n = 9 animals) or to CORT (n = 42) for 10 weeks. On Week 10, CORT group have been divided in four groups receiving either CORT (n = 10), CORT + VENLA (15 mg/kg/day in the drinking water; n = 10), CORT + CBX (10 mg/kg/day; i.p.; n = 10) or the combination of the three of them CORT + VENLA + CBX (n = 12). On Week 18, VENLA and CBX treatments were stopped, whereas CORT was maintained for all the groups. Emotionality z-score were calculated at Week 18 (EM1) and Week 23 (EM2) to respectively assess responsiveness and relapse to VENLA or VENLA + CBX treatment. (B–E) Anxio-/depressive-like behavior. Data are mean ± SEM of mice performances in the open field (B), novelty-suppressed feeding (C), tail suspension tests (D) and splash test (E). Asterisks indicate statistical significance on raw data. * p < 0.05, ** p < 0.01 and *** p < 0.001: Statistically different as indicated.