Table A1.
Cumulative CO exposure calculation based on RESPIRE and CRECER 48-h personal CO tube measurements.
| Time | Values | Main Analysis | Alternative 1 | Alternative 2 | Alternative 3 |
|---|---|---|---|---|---|
| Birth | X1 | X1 | X1 | (X1 + X2 + X3)/3 | |
| - | X1 | X1 | X1 | (X1 + X2 + X3)/3 | |
| RESPIRE CO tube 1 | X1 | X1 | X1 | X1 | (X1 + X2 + X3)/3 |
| - | X2 | X2 | X2 | (X1 + X2 + X3)/3 | |
| RESPIRE CO tube 2 | X2 | X2 | X2 | X2 | (X1 + X2 + X3)/3 |
| - | X3 | X3 | X3 | (X1 + X2 + X3)/3 | |
| Last RESPIRE CO tube | X3 | X3 | X3 | X3 | (X1 + X2 + X3)/3 |
| - | X3 | (X3 + X4)/2 | X4 | (X1 + X2 + X3)/3 | |
| ~18 months old (600 days) | X3 | (X3 + X4)/2 | X4 | (X4 + X5 + X6 + X7)/3 | |
| - | X4 | (X3 + X4)/2 | X4 | (X4 + X5 + X6 + X7)/3 | |
| - | X4 | (X3 + X4)/2 | X4 | (X4 + X5 + X6 + X7)/3 | |
| - | X4 | (X3 + X4)/2 | X4 | (X4 + X5 + X6 + X7)/3 | |
| CRECER CO tube 1 | X4 | X4 | X4 | X4 | (X4 + X5 + X6 + X7)/3 |
| - | X5 | X5 | X5 | (X4 + X5 + X6 + X7)/3 | |
| CRECER CO tube 2 | X5 | X5 | X5 | X5 | (X4 + X5 + X6 + X7)/3 |
| - | X6 | X6 | X6 | (X4 + X5 + X6 + X7)/3 | |
| Last CRECER CO tube before first QRQ | X6 | X6 | X6 | X6 | (X4 + X5 + X6 + X7)/3 |
| - | X6 | X6 | X6 | (X4 + X5 + X6 + X7)/3 | |
| First QRQ | X6 | X6 | X6 | (X4 + X5 + X6 + X7)/3 | |
| - | 0 | 0 | 0 | 0 | |
| CRECER CO tube after first QRQ | X7 | 0 | 0 | 0 | 0 |
Note: this table is simplified to include 3 RESPIRE measurements and 3 CRECER measurements before first QRQ (Quarterly Respiratory Questionnaire). The number of CO tube measurements during each study period can be different among study children.