Table 2.
Comparison of extraction efficiency [%] obtained for each compound in different pH conditions and with the use of various extraction solvents.
| Extraction Efficiency [%] | |||||
|---|---|---|---|---|---|
| Mifepristone | N-Desmethyl Mifepristone | N,N-Didesmethyl Mifepristone | 22-OH-Mifepristone | ||
| pH 7.4 | Ethyl acetate | 50.3 | 60.1 | 46.8 | 56.1 |
| n-Hexane | 20.7 | 2.9 | 8.9 | 0.2 | |
| DCM | 29.8 | 54.8 | 52.2 | 47.2 | |
| TBME | 55.9 | 68.5 | 69.0 | 89.0 | |
| pH 9 | Ethyl acetate | 49.0 | 65.6 | 61.7 | 78.5 |
| n-Hexane | 16.7 | 2.8 | 7.8 | 0.2 | |
| DCM | 20.0 | 36.9 | 55.9 | 64.0 | |
| TBME | 62.0 | 71.1 | 73.0 | 94.4 | |
Abbreviations: DCM—dichloromethane, TBME—tert-butyl-methyl ether.