Table 1.
Demographic data, MRI, evoked potentials and cerebrospinal fluid analysis in PPMS and SPG4 patients.
| PPMS | SPG4 | ||
|---|---|---|---|
| Age at serum sampling (years) | 53.8 (48.8–60.5) | 56.2 (48.9–62.5) | |
| Age at onset (years) | 47.0 (35.5–53.0) | 47.0 (39.0–51.0) | |
| Disease duration (years) | 7.7 (3.8–13.4) | 11.2 (7.3–15.5) | |
| MRI (T2-hyperintense lesions) |
periventricular | 25/25 | 3/19 (consistent with cerebral microangiopathy) |
| juxtacortical | 24/25 | ||
| infratentorial | 19/25 | 1/19 (consistent with pontine microangiopathy) | |
| spinal | 21/24 | 0/17 | |
| CSF | Pleocytosis (>5 cells per μL) |
6/19 | 0/9 |
| Abnormal IgG Index (>0.7) |
7/12 | 0/6 | |
| Positive OCB | 19/22 | 0/5 | |
| Abnormal MEP | Upper limbs | 9/12 | 0/17 |
| Lower limbs | 13/15 | 10/18 | |
| Abnormal SEP | Upper limbs | 5/7 | 0/4 |
| Lower limbs | 13/14 | 6/10 | |
| Abnormal VEP | 12/15 | 0/3 | |
X/Y, X number of patients with abnormal findings, Y number of all patients with available data (e.g., spinal MRI was available in 24 PPMS patients and abnormal in 21 of those patients); MRI, magnetic resonance imaging; CSF, cerebrospinal fluid; OCB, oligoclonal bands; MEP, motor evoked potentials; SEP, somatosensory evoked potentials; VEP, visual evoked potentials. Values of age at serum sampling, age at onset and disease duration are detailed as medians and interquartile ranges.