Table 3.
Allelic/genotype combinations most significantly associated with longevity according to APSampler analysis.
| Combinations | Compared Age Periods # | P | PBonf | OR | CIOR | ||||
|---|---|---|---|---|---|---|---|---|---|
| 18–74 | 18–89 | 60–89 | 75–89 | 90–113 | |||||
| LAMA2 Ya5-MLS19*ID + CDH4 Yb8NBC516*DD + HECW1 Ya5NBC182*D | 3.77 | 15.22 | 1.70 × 10−6 | 9.00 × 10−3 | 4.58 | 2.56–8.21 | |||
| LAMA2 Ya5-MLS19*D + CDH4 Yb8NBC516*DD + HECW1 Ya5NBC182*D | 4.76 | 17.39 | 1.09 × 10−5 | 2.60 × 10−2 | 4.21 | 2.23–7.96 | |||
| LAMA2 Ya5-MLS19*D + CDH4 Yb8NBC516*DD + ACE Ya5ACE*I | 6.02 | 19.08 | 7.76 × 10−6 | 1.90 × 10−2 | 3.68 | 2.09–6.49 | |||
| LAMA2 Ya5-MLS19*ID + CDH4 Yb8NBC516*D + SEMA6A Yb8NBC597*I | 8.37 | 22.22 | 1.08 × 10−5 | 2.00 × 10−2 | 3.13 | 1.90–5.16 | |||
| LAMA2 Ya5-MLS19*ID + CDH4 Yb8NBC516*D | 28.12 | 46.58 | 3.76 × 10−6 | 1.90 × 10−2 | 2.23 | 1.59–3.13 | |||
| LAMA2 Ya5-MLS19*ID + HECW1 Ya5NBC182*I | 40.75 | 60.27 | 8.29 × 10−6 | 1.90 × 10−2 | 2.21 | 1.55–3.15 | |||
Abbreviations: #—the data for the compared age groups are presented as the frequencies of allelic/genotype combinations (%); D—Alu deletion allele; I—Alu insertion allele; the asterisk is used to separate the name of polymorphism and allele or genotype; P—significance level estimated using Fisher’s exact test; PBonf—significance level corrected for multiple testing using Bonferroni correction; OR—odds ratio; CIOR—95% confidence interval for OR.