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A schematic representation for the AT1 receptors and phospholipase C mediated signal transduction pathways for the development of Angiotensin II- induced cardiac hypertrophy. The activation of AT1R has been shown to promote Ca2+—entry through sarcolemmal Ca2+ channels and increase the intercellular concentration Ca2+, which may also contribute to activating Ca2+ calmodulin kinase for the occurrence of cardiac hypertrophy.
