Figure 1.

Proanthocyanidin (PAC) cluster obtained by molecular networking (MN) of grape seed extract (GSE) and its alkalinized version (ATGSE). The nodes (circles) represent a consensus MS/MS spectrum having identical precursor mass obtained from the samples, and the colors of the nodes refer to the unique property of the compound present or absent in the two samples. Blue nodes were identified in the GSE extract. Instead, red nodes represent compounds in common in the two extracts. The edges (lines) connect the nodes based on the “cosine score” (fragment match/similarity score ranging from 0.7 to 1), and the thickness of the edges reflects and measures the positive relatedness of the MS/MS spectra of the compounds within a network.