Table 3.
Univariate analysis of predictive factors associated with transient and permanent hypoparathyroidism.
| No n = 1312 |
Transient n = 209 |
p | Permanent n = 26 |
p′ | |
|---|---|---|---|---|---|
| Patient characteristics | |||||
| Female gender | 989 (75.4) | 182 (87.1) | <0.001 | 22 (84.6) | 0.360 |
| Age (years) | 49.8 ± 14.4 | 45.9 ± 14.4 | <0.002 | 41.1 ± 13.6 | 0.002 |
| Indication of thyroidectomy | |||||
| Benign goiter | 791 (60.3) | 91 (43.5) | <0.001 | 9 (34.6) | 0.028 |
| Toxic nodule or goiter | 108 (8.2) | 25 (12) | 4 (15.4) | ||
| Suspect thyroid nodule | 413 (31.5) | 93 (44.5) | 13 (50) | ||
| Surgery | |||||
| Thyroid weight (gr) | 53.8 ± 48.6 | 53.4 ± 48.9 | 0.926 | 50.6 ± 47.1 | 0.753 |
| Number of parathyroid glands seen | 3.2 ± 0.8 | 3.3 ± 0.8 | 0.064 | 3.2 ± 0.8 | 0.971 |
| Number of parathyroid glands autotransplantated | 0.2 ± 0.4 | 0.4 ± 0.7 | <0.001 | 0.3 ± 0.6 | 0.167 |
| Lymph node dissection | |||||
| Central lymph node dissection | |||||
| Ipsilateral CLNS | 33 (2.5) | 5 (2.4) | 1 | 1 (3.8) | 0.491 |
| Ipsilateral CLND | 113 (8.6) | 32 (15.3) | 0.003 | 2 (7.7) | 1 |
| Bilateral CLND | 137 (10.4) | 48 (23.0) | <0.001 | 9 (34.6) | 0.001 |
| Lateral lymph node dissection | |||||
| Ipsilateral LLNS | 54 (4.1) | 9 (4.3) | 0.852 | 1 (3.8) | 1 |
| Bilateral LLNS | 101 (7.7) | 20 (9.6) | 0.337 | 3 (11.5) | 0.448 |
| Ipsilateral LLND | 103 (7.9) | 32 (15.3) | 0.001 | 2 (7.7) | 1 |
| Bilateral LLND | 40 (3) | 12 (5.7) | 0.062 | 5 (19.2) | 0.001 |
| Histology | |||||
| Micropapillary thyroid cancer | 669 (51) | 98 (46.9) | 0.780 | 12 (46.2) | 0.915 |
| Papillary thyroid cancer | 483 (36.8) | 86 (41.1) | 11 (42.3) | ||
| Follicular thyroid cancer | 85 (6.5) | 12 (5.7) | 1 (3.8) | ||
| Medullary thyroid cancer | 70 (5.3) | 12 (5.7) | 2 (7.7) | ||
| Poorly differentiated cancer | 5 (0.4) | 1 (0.5) | 0 (0) | ||
| Tumor size (mm) | 13.3 ± 17.2 | 15.4 ± 19.3 | 0.116 | 13.5 ± 14.4 | 0.960 |
| Stade T | |||||
| T1 | 984 (75.1) | 143 (68.4) | 0.031 | 18 (69.2) | 0.453 |
| T2 | 155 (11.8) | 27 (12.9) | 2 (7.7) | ||
| T3–T4 | 172 (13.1) | 39 (18.7) | 6 (23.1) | ||
| Stade N | |||||
| N0 | 108 (8.2) | 22 (10.5) | 0.038 | 6 (23.1) | 0.414 |
| N1a | 32 (2.4) | 16 (7.7) | 0 (0) | ||
| N1b | 118 (9.0) | 43 (20.6) | 5 (19.2) | ||
| Parathyroid glands on specimen | 79 (6.0) | 28 (13.4) | <0.001 | 8 (30.8) | <0.001 |
Data are presented as mean ± standard deviation or n (%). p for comparison between no hypoparathyroidism and transient hypoparathyroidism. p′ for comparison between no hypoparathyroidism and permanent hypoparathyroidism. p and p′ values are derived from a Chi-squared test or Fisher’s exact test for nominal variables and from Student’s t-test for continuous variables.