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. 2022 Nov 4;14(21):5433. doi: 10.3390/cancers14215433

Figure 1.

Figure 1

Effect of tumor mutational burden (TMB) on overall survival after ICI treatment. Kaplan–Meier (KM) curves for patients with tumors within each TMB predefined cutoff. Overall survival was from the first dose of ICIs. Median OS was 42 months for both TMB ≥ 20mut/Mb and TMB ≥ 10 mut/Mb, and 15 months for TMB < 10 mut/Mb, multivariate log-rank p < 0.005. Cox regression HRs for death were 0.44 (95% CI 0.34–0.56) and 0.57 (95% CI 0.49–0.67) for TMB ≥ 20 mut/Mb and ≥ 10 mut/Mb, respectively (p < 0.005). No difference was observed in death risk between cohorts with TMB 10 mut/Mb or less and 1 mut/Mb or less (HR 0.96; 95% CI 0.74–1.24; p = 0.73). ICIs = immune checkpoint inhibitors.