Table 1.
Participant characteristics.
| Characteristic | Cirrhosis Cases | HCC Cases | Controls |
|---|---|---|---|
| Total N | 68 | 94 | 91 a |
| % Male | 51.5% | 57.5% | 57.1% |
| Median Age at Sample Date (Range) | 54.0 (34–65) | 55.5 (34–65) | 56.0 (30–65) |
| Median Year of Serum Collection (Range) | 1991 (1991–1992) | 1993 (1992–1997) | 1993 (1992–1996) |
| Median Years of Follow-up (Range) * | 19.9 (7.5–20.9) | 15.3 (3.6–20.8) | 19.9 (2.1–20.8) |
| Median BMI (Range) | 24.4 (17.9–32.3) | 25.0 (18.4–37.6) | 23.3 (18.6–33.7) |
| ALT, N (%) | |||
| <15 | 19 (27.9) | 20 (21.3) | 31 (34.1) |
| 15–44 | 36 (52.9) | 40 (42.6) | 42 (46.2) |
| ≥45 | 13 (19.1) | 34 (36.2) | 18 (19.8) |
| Smoking | |||
| No | 51 (75.0) | 54 (57.5) | 64 (70.3) |
| Yes | 17 (25.0) | 40 (42.5) | 27 (29.7) |
| Alcohol drinking | |||
| No | 63 (92.7) | 85 (90.4) | 82 (90.1) |
| Yes | 5 (7.3) | 9 (9.6) | 9 (9.9) |
| Family history of HCC | |||
| No | 67 (98.5) | 93 (98.9) | 88 (96.7) |
| Yes | 1 (1.5) | 1 (1.1) | 3 (3.3) |
| Baseline RNA positivity † | |||
| No | 14 (20.6) | 8 (8.5) | 8 (8.8) |
| Yes | 51 (75.0) | 86 (91.5) | 83 (91.2) |
| Median HCV RNA level at sample date | 17,400 | 40,400 | 25,700 |
| Median time to event in years (Range) | 10.75 (0.37–19.02) | 13.3 (2.29–21.59) | - |
a Three controls were double matched to cases. * Time from baseline/entry to HCC diagnosis, death, or end of study (31 December 2011), whichever came first. † Numbers do not add to total due to missing values. Abbreviations: BMI, body mass index; ALT, alanine aminotransferease; HCC, hepatocellular carcinoma.