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The mechanism of thyroid hormones synthesis in hypothyroidism with defective thyroglobulin. Thyrocytes under massive ER stress (left) lose epithelial cell-cell contact, likely from diminished cell junctional integrity, and progress to cell death (right). Dying thyrocytes that have been extruded into the follicle lumen eventually disintegrate and their macromolecular components are exposed to iodination and ingestion by surrounding live thyrocytes.
