FIG. 3.
(A) Dynamics of middle ear colonization in CFU of NTHI per milliliter of fluids recovered from adenovirus-infected chinchilla cohorts immunized as indicated and challenged t.b. and i.n. with NTHI 86-028NP. Only four cohorts which demonstrated moderate to significantly augmented clearance plus the naive and adjuvant-only control cohorts are included. (B) NP colonization dynamics in CFU of NTHI per milliliter of lavage fluid of adenovirus-infected chinchilla cohorts immunized as indicated and challenged with NTHI 86-028NP. Only three cohorts which demonstrated moderate to significantly augmented clearance plus naive and adjuvant-only cohorts are included. The asterisk at day 0 indicates the inoculum of NTHI instilled (108 CFU). Results are means and standard deviations (number of determinations were six per cohort for days 1 to 10 and five per cohort for days 14 to 35).