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. 2022 Oct 30;27(21):7374. doi: 10.3390/molecules27217374

Table 1.

Types of non-associative and associative learning.

Category Subcategory Paradigm Further Subcategory Behavioral Response Example Reference
Non-associative learning
Habituation - Continuous exposure of stimulus - Decrease Reduced zebrafish startle response to repeated sound stimulus [19]
Sensitization - - Increase Repeated nicotine exposure increased locomotor activity and sensitivity of zebrafish [20]
Associative learning
Classical (Pavlovian) Appetitive conditioning Association of favorable stimulus with cue - Increase/Decrease
(involuntary response)
Increased dog salivation upon hearing sound of bell that was previously paired with food -
Aversive conditioning Association of unfavorable stimulus with cue - Increase/Decrease
(involuntary response)
Decreased zebrafish distance traveled in tank that was previously paired with electric shock (Increased contextual fear response) [21]
Increased zebrafish freezing time and erratic movement in tank that was previously paired with electric shock (Increased contextual fear response) [22]
Operant (Instrumental) Positive reinforcement Association of behavioral response with administration of appetitive stimulus - Increase Increased zebrafish approach to a response key that was equipped with a sensor to dispense brine shrimp eggs [23]
Negative reinforcement Association of behavioral response with removal of aversive stimulus Escape learning
(Engage a behavior to remove the existing aversive stimulus)
Increase Increased rodent crossing response from a compartment with existing foot shock to the opposite compartment in a shuttle box -
Active avoidance
(Engage a behavior to prevent the occurrence of aversive stimulus)
Increased zebrafish crossing response to a compartment without electric shock upon the presentation of light signal that was previously paired with administration of the shock [24]
Passive (inhibitory) avoidance
(Suppress an innate behavior to prevent the occurrence of aversive stimulus)
Increased zebrafish latency to enter dark (preferred) compartment that was previously paired with electric shock [25]
Positive punishment Association of behavioral response with administration of aversive stimulus - Decrease Refrained from pressing a lever that will lead to foot shock for a rodent -
Negative punishment Association of behavioral response with removal of appetitive stimulus - Decrease Decreased the undesired behavior by taking away the reward in a dog training -