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. 2022 Oct 28;23(21):13070. doi: 10.3390/ijms232113070

Figure 2.

Figure 2

Parabacteroides goldsteinii (Pg) MTS01 ameliorates the anxiety-like behaviors of MIAO. Offspring from phosphate-buffered sale control group (CTL, n = 30), LPS-induced MIA group (MIAO, n = 30), and MIAO orally gavaged with Pg MTS01 (MIAO + Pg, n = 30) were evaluated for anxiety-like behaviors using the open-field test (OFT; A–C), light–dark box (D–F), and elevated plus maze (G–I). The central and peripheral regions in 36 squares as well as the representative path tracing during the OFT are presented (A). The proportion of time spent in the central region (B) and the total distances moved in the test period (C) are presented. A schematic representation of the LDB is presented (D). The number of times the mice moved between the light and dark boxes within 10 min were recorded (E), and the proportion of time spent in the dark box (F) is presented. A schematic representation of the EPM test is presented (G). The proportion of open arm entries (H) and the time spent in the open arm (I) are presented. Data are presented as the mean ± standard deviation. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant (one-way ANOVA, Tukey’s post hoc test).