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. 2022 Oct 28;23(21):13070. doi: 10.3390/ijms232113070

Figure 3.

Figure 3

Parabacteroides goldsteinii (Pg) MTS01 ameliorates the social deficit behaviors of MIAO. Offspring from the phosphate-buffered saline control group (CTL), lipopolysaccharide-induced MIA group (MIAO), and MIAO orally gavaged with Pg MTS01 (MIAO + Pg) were evaluated for social deficit behaviors using the home cage test (n = 46; A,B) and three-chamber behavioral test (3-CBT, n = 34; C–F). A schematic representation of the phenotypic expression of active (nose-to-nose or nose-to-body) and passive (body-to-body) behaviors is presented (A). The number of times that passive behaviors were displayed was recorded (B). Schematic representation of the 3-CBT is presented (C,E). The proportion of time spent in the empty chamber (Object zone) in contrast to that in the Social zone was recorded (D). The proportion of time spent exploring unfamiliar (S2 zone) in contrast to familiar mice (S1 zone) is presented (F). Data are presented as the mean ± standard deviation. * p < 0.05; **** p < 0.0001 (one-way ANOVA, Tukey’s post hoc test).